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Cystic fibrosis: Restoring airway integrity

Cystic fibrosis is a rare genetic disease which can cause very serious symptoms. In particular, patients suffer from chronic bacterial infections that can lead to respiratory failure. It is caused by mutations in the CFTR gene, which regulates water movement across the cell membrane. Consequently, mucus quality is altered, it...

Reference genomes provide first insights into genetic roots of mustelid physiological and behavioral diversity

Mustelids are the most ecologically and taxonomically diverse family within the order Carnivora. From the tayra in the neotropics to the wolverine in the subarctic, they inhabit a variety of ecological niches and developed corresponding species-specific traits related to their diet, reproductive strategy and morphology. An international team of scientists...

Microbes can degrade the toughest PFAS

Engineers now report selective breakdown of a particularly stubborn class of PFAS called fluorinated carboxylic acids (FCAs) by common microorganisms. Under anaerobic conditions, a carbon-carbon double bond is crucial for the shattering the ultra-strong carbon-fluorine bond by microbial communities. The resulting products could be relayed to other microorganisms for defluorination...