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Editing without ‘cutting’: Molecular mechanisms of new gene-editing tool revealed

New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms...

Grow the skin you’re in: In vivo generation of chimeric skin grafts

Researchers found that mutated mouse embryos showing an abnormal epidermal differentiation and injected with mouse pluripotent stem cells grew large patches of mature epidermis derived from the donor cells that survived transplantation to adult mice and grew natural-looking fur. Injecting the embryos with human keratinoctyes produced sheets of semi-humanized skin,...