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Novel genomic screening tool enables precision reverse-engineering of genetic programming in cells

Collaborative research defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation. The method, called 'Perturb-multiome,' uses CRISPR to knock out the function of individual transcription factors across many blood cells at once. The researchers then perform single-cell...

Climate change and prehistoric human populations: Eastward shift of settlement areas at the end of the last ice age

An archaeological study of human settlement during the Final Palaeolithic revealed that populations in Europe did not decrease homogenously during the last cold phase of the Ice Age. Significant variation in regional population sizes indicate differentiated reactions nested in an overall shift of settlement areas towards the east.